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The Clinical Trials Registry—India (CTRI) is

an initiative of the Indian Council of Medical Research, New Delhi, India (ICMR) and monitored by the ICMR-National Institute of Medical Statistics (NIMS) since July 20, 2007. Randomized clinical trials are considered as the gold standard in evidence-based medicine. Registration of clinical trials enables disseminating evidence among clinicians, researchers, and patients. It promotes transparency and avoids duplication. The registration process is mandatory for AYUSH clinical trials also.

Objectives

This analysis is aimed to determine the different characteristics of registered AYUSH clinical trials in CTRI from 2009 to 2020.

Materials and methods

A cross-sectional retrospective analysis was conducted. The information on registered clinical trials about AYUSH was obtained from the website www.ctri.nic.in from 2009 to 2020 (n = 3632; last accessed on July 30 2020). Data analysis considered the following factors for analysis using descriptive statistics. The number of clinical trials registered in AYUSH stream were classified according to registration type (retrospective/prospective), postgraduate dissertations (yes/no), primary sponsor, type of trial (interventional/observational), study design, health condition and State-wise distribution of sites of studies.

Results

The number of clinical trial registrations among AYUSH streams (3632) descends from Ayurveda (2054), followed by Siddha (635), Yoga (408), Unani (366) and Homoeopathy (169). Interventional studies dominate observational studies among all AYUSH registered trials. AYUSH streams took four years to register in CTRI due to an increase in reporting trials from 2013. Significant number of trials were registered retrospectively. The order of closure of retrospective registration has influenced an increase in prospective enrolment between 2017–2019.

Conclusion

Registration of clinical trials in the CTRI should be encouraged. Randomized controlled trials (RCTs) occupy a rear seat which exposes an opportunity for trials and alarms about weak trials. Non-communicable diseases (NCDs) are registered more comparatively, which reflects the strength of AYUSH in NCDs. Most of the trials fall under phase 2, which seems to have an increasing opportunity for more trials. Certain visible flaws like registering Phase 2 trials as Phase 3 or 4 and domestic trials as international trials reflect human resources crunch in ICMR-CTRI in Issuing Certificates. These errors should be rectified by training the stakeholders effectively.

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Functional Recovery in Bilateral Knee Osteoarthritis (Azhal Keel Vayu) :A Siddha Nano Medicine Approach


Functional Recovery in Bilateral Knee Osteoarthritis (Azhal Keel Vayu) :

A Siddha Nano Medicine Approach

Mr ……x/73 years
Chief Complaints:
Bilateral knee joint pain with swelling, restricted mobility, difficulty in walking, inability to perform floor sitting and routine ADLs. Patient was walking-aid dependent (stick) for the past 8 years.
History revealed inability to attend family functions and inability to board public transport - “பேருந்து மற்றும் இரு சக்கர வாகனங்களில் ஏறி பயணம் செய்ய இயலாத நிலை”. Previously advised for surgical intervention for OA knee by Orthopedics, patient was unwilling for surgery and sought Siddha line of management for degenerative OA.

Diagnosis:

Azhal Keel Vayu correlated with Bilateral Osteoarthritis Knee - degenerative stage.

Management Plan :

Inpatient based integrated Siddha protocol:
Advised IPD admission for comprehensive care aiming at pain management and restoration of normal gait.
Therapeutic Protocol:
External & Palliative Care:

Siddha poly herbal combination oil application for pain & joint flexibility
•  Medicated oil massage (Thokkanam)
•  Hot oil fomentation (Ottradam)
•  Polyherbal analgesic paste application (Patru)
•  Siddha Varma therapy for joint stabilization
Vatha Management:
•  Strict Vatha reduction diet plan
Internal Medicine:
•  Mukkutra neutralizing oil bath (Mukutra Ennai Kuliyal)
•  Vatha-reducing purgative (Virechanam) for gut detoxification - considering Gut-Joint axis
•  Followed by Siddha Nano Medicine - BD dose for 3 days per course
Total 4 courses were given with 1-week drug holiday between courses.
Clinical Course & Outcome (35-day IPD observation):

•  After Course 1: Significant reduction in pain and swelling noted.
•  After Course 2: Complete resolution of joint swelling, moderate pain reduction.
•  After Course 3: Further improvement in pain, swelling; patient able to walk short distances without walking stick.
•  After Course 4: Remarkable functional improvement - able to walk without support, able to sit on floor, restored ADLs. Pain and swelling significantly reduced.

Discussion:

This case demonstrates the potential of Siddha system in managing chronic degenerative Azhal Keel Vayu. The combination of Vatha-diet plan purgation and oil bath ,External therapies, Varma, and targeted Nano medicine addresses not only pain but joint flexibility and systemic Vatha aggravation.

Individual results may vary. Non-surgical Siddha management can be explored in elderly patients unwilling/unfit for surgery.
With the blessings of Siddhars.


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Advancing Siddha Medicine Delivery Through Bilayer Tablet TechnologyTraditional Siddha medicine includes dosage forms such as Chooranam (herbal powders), Parpam and Chendhuram (herbo-mineral/mineral preparations), which are sometimes administered in combination based on traditional therapeutic principles. However, conventional co-administration may present practical challenges related to dose accuracy, handling of multiple dosage forms, dosing frequency, patient convenience, and compliance.Bilayer tablet technology offers an innovative pharmaceutical approach by incorporating the herbal and herbo-mineral components into a single dosage form with two distinct layers. This approach provides an opportunity to improve dose precision, patient convenience, formulation stability, and flexibility in drug-release characteristics, while retaining the underlying concept of combined administration.Why Bilayer Tablets?🔹 Improved Patient Convenience – Multiple powders or dosage forms can potentially be consolidated into a single tablet, simplifying administration.🔹 Dose Precision – Defined quantities of herbal and herbo-mineral components can support more consistent dosing than manual measurement of separate preparations.🔹 Layer-wise Separation – Physical separation of the components may help minimize undesirable interactions between the two layers prior to administration and supports formulation stability.🔹 Controlled Release Potential – Bilayer design provides flexibility to develop different release profiles, including immediate, sustained, or synchronized release, according to the intended therapeutic objective.Towards Standardization and Scientific ValidationOur review proposes a structured framework for the development, optimization, characterization, and testing of herbal–herbo-mineral bilayer tablets, incorporating modern pharmaceutical approaches such as pre-formulation studies, HPTLC, ICP-OES, FTIR, DSC, XRPD, dissolution and release-kinetics studies, stability assessment, and Quality by Design (QbD).The work aims to provide a scientific foundation for developing standardized and reproducible SOPs for Siddha bilayer tablets, while considering applicable testing frameworks and broader global pharmaceutical development principles.From Traditional Wisdom to Modern Pharmaceutical InnovationThis review represents an effort to bridge traditional Siddha therapeutic concepts with contemporary pharmaceutical technology, with the long-term vision of improving quality, safety, reproducibility, patient acceptability, and scientific validation of Siddha dosage forms.Heartfelt congratulations to the entire research team for this collaborative work, and sincere gratitude to the Central Council for Research in Siddha (CCRS), Ministry of Ayush, for the financial and institutional support provided through the IMR project, “Formulation and optimization of Orally Disintegrating Tablet (ODTs), Single and Bilayer tablet formulations to be developed in Siddha System of Medicine to Enhance Patient Compliance.”Research Team:Dr. M. S. Shree Devi • Mr. Ashwin Kumar K • Dr. P. Sathiyarajeswaran • Dr. S. Vinayak • Dr. N. J. MuthukumarBilayer Tablet Technology in Ayush Systems: Formulation Strategies, Challenges, and Quality Evaluation of Herbal–Herbo Mineral Dosage Forms — International Journal of Drug Delivery Technology, 2026; 16(73s):1643–1649.https://www.academia.edu/171396199/Bilayer_Tablet_Technology_in_Ayush_Systems_Formulation_Strategies_Challenges_and_Quality_Evaluation_of_Herbal_Herbo_Mineral_Dosage_Forms?fbclid=IwY2xjawTmXLNwZG9mBWV4dG4DYWVtAjExAHNydGMGYXBwX2lkEDIyMjAzOTE3ODgyMDA4OTIAAR5I4Du_aq7En88_MxsuGVq483QsxLuRm3BpB4Da0npKO79Dt5_nDiAu_ziG6g_aem_W6f_krgFE9Aj2d6RbGQWKA

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Madhulai Manapagu has been successfully converted from a traditional liquid syrup into a modern Oral Dissolving Film (ODF) that dissolves on the tongue in just ~40 seconds, making it a game-changer for pediatric emesis and oncology-supportive care! Through lyophilization (freeze-drying), the extract is preserved with enhanced stability, precise dosing, and no need for refrigeration or water—making it truly portable, patient-friendly, and ideal for children and cancer patients who struggle with nausea and vomiting! And the innovation doesn't stop there—this same lyophilized extract can also be converted into Gummies, offering yet another child-friendly, tasty, and convenient dosage form for everyday wellness and supportive care!This value-added innovation enhanced the utility of 5000 years of Siddha wisdom—transforming a time-honoured remedy into a cutting-edge therapeutic solution and opening doors for global commercialization of traditional medicine in modern healthcare!👉 Read the full research: https://lnkd.in/gtc4NNhw#MadhulaiManapagu #SiddhaInnovation #FormConversion #ValueAddition #OralDissolvingFilm #PaediatricEmesis #OncologySupportiveCare #HerbalGummies #TamilNadu #HerbalTechnology #SiddhaForTheWorld #TraditionalMedicineModernScience #CCRS #SCRI #SRRI #Siddha #SiddhaResearch #SiddhaPharmacy #SiddhaMedicine #NCISM #BUSS

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🔶 Structured Naadi Training Programme at NIS 🔶The National Institute of Siddha invites registered Siddha practitioners to enroll in its 3-month Structured Naadi Training Programme designed to enhance diagnostic proficiency and strengthen Naadi-based clinical skills.🩺 Sharpen your expertise in traditional Naadi assessment📚 Duration: 3 Months📅 Schedule: 2 Classes per MonthThis programme offers a systematic approach to mastering Naadi examination, integrating classical Siddha principles with practical clinical application.📌 Programme Highlights:✔️ Structured Naadi diagnostic training✔️ Clinical correlation with case discussions✔️ Guidance from experienced Siddha experts✔️ Certification on successful completion📥 Download Brochure & Details:👉 https://nischennai.org/main/wp-content/uploads/2026/03/nis-naadi-workshop-apr-2026.pdf📝 Register Here:👉 https://docs.google.com/forms/d/e/1FAIpQLSf9_4FuJ_DXBgtZw35LcIWcCsPGz1cZNyLgyzrQJ0CHucWAJQ/viewform⚠️ Limited seats available – Register early to secure your participation!#SiddhaMedicine #NaadiPariksha #NIS #AYUSH #ClinicalTraining #TraditionalMedicine

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Title: Why is it called so? – Decoding the symbolism in Siddha classical textsStart time: 11 March 2026 03:00 PM Asia/KolkataURL: https://bharatvc.nic.in/join/7693481498Conference ID: 7693481498Password: 618908Description: Why is it called so? – Decoding the symbolism in Siddha classical textsJoin via H.323URL: 7693481498@164.100.174.44 / 164.100.174.44##7693481498PIN: 725403Join via SIPURL: 7693481498@bhvc.nic.in / bhvc.nic.inPIN: 725403Use Google Chrome/Microsoft Edge or Native Apps for better experience

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Anticancer drugs in Siddha literature for Cervical cancer -A review ..Dr.K.Elavarasan

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Siddha medicine and Varmam therapy for Cerebral palsy children -SirakambavathamClinical trial at Department of Kuzhanthaimaruthuvam -National institute of Siddha, Ministry of Ayush Government of India.I sincerely thank to My teachers,and Guide of research work.

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